Statistics Collaborative - Design and analysis for biomedical research


Matthew Downs

  • Nickel M, Simonati A, Jacoby D, Lezius S, Kilian D, Van de Graaf B, Pagovich OE, Kosofsky B, Yohay K, Downs M, Slasor P, Aiayi T, Crystal RG, Kohlschütter A, Sondhi D, Schulz A. Disease characteristics and progression in patients with late-infantile neuronal ceroid lipfuscinosis type 2 (CLN2) disease: an observational cohort study. The Lancet 2018; 2:582-590.

  • Buhr KA, Downs M, Rhorer J, Bechhofer R, Wittes J. Reports to independent data monitoring committees: An appeal for clarity, completeness, and comprehensibility. Therapeutic Innovation and Regulatory Science 2018; 52:459-468.

  • Schulz A, Nickel M, Downs M, Mezey J, Landy H, Sondhi D, Jacoby D, Wittes J, Crystal R, Kohlschütter A. The natural history of late infantile CLN2 disease: striking homogeneity of clinical progression in two independently obtained large clinical cohorts. European Journal of Paediatric Neurology 2013 and Annals of Neurology 2013.

  • Whyte MP, Greenberg CR, Salman NJ, Bober MB, McAlister WH, Wenkert D, Van Sickle BJ, Simmons JH, Edgar TS, Bauer ML, Hamdan MA, Bishop N, Lutz RE, McGinn M, Craig S, Moore JN, Taylor JW, Cleveland RH, Cranley WR, Lim R, Thacher TD, Mayhew JE, Downs M, Millan JL, Skrinar AM, Crine P, Landy H. Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med 2012; 366:904-913.
  • Downs M, Tucker K, Christ-Schmidt H, Wittes J. Some practical problems in implementing randomization. Clin Trials 2010; 7:235-245.
  • Ben Salah A, Buffet PA, Morizot G, Ben Massoud N, Zaatour A, Ben Alaya N, Haj Hamida NB, Ahmadi ZE, Downs MT, Smith PL, Dellagi K, Grogl M. Wr279,396, a third generation aminoglycoside ointment for the treatment of leishmania major cutaneous leishmaniasis: A phase 2, randomized, double blind, placebo controlled study. PLoS Negl Trop Dis 2009; 3:e432.
  • Wittes J, Downs M. Outcome measures to assess efficacy of treatments for age-related macular degeneration. Ophthalmology 2009; 116:S8-14.
  • Christ-Schmidt H, Downs M. A SAS Macro to Generate Enhanced Kaplan Meier Plots. Proceedings of the Eighteenth Annual Conference of the Northeast SAS Users Group 2004.
  • Christ-Schmidt H, Downs M. A SAS Macro to Generate Enhanced Kaplan Meier Plots. Proceedings of the Thirtieth Annual Conference of the SAS Users Group International Conference 2004.
  • Mitsuyasu R, Anton P, Deeks S, Scadden D, Connick E, Downs M, Bakker A, Roberts M, June C, Jalali S, Lin A, Pennathur-Das R, Hege K. Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood 2000; 96:785-793.
  • Downs M, Foulkes M. Review of "Management of Data in Clinical Trials" by E. McFadden. The Statistician 1999; 48:154.