Statistics Collaborative - Design and analysis for biomedical research

Therapeutic AreasTherapeutic Areas

HIV/AIDS

Statistics Collaborative, Inc. (SCI) has proven experience on a range of issues related to HIV/AIDS, both in prevention and in treatment. We have worked with industry clients to provide Data Monitoring Committee (DMC) support for novel or reformulated treatment methods for HIV-infected patients.

Dr. Wittes has served on many committees dealing with HIV/AIDS both while she was employed by the National Heart, Lung, and Blood Institute (NHLBI) and during her tenure at SCI.

Examples of SCI’s work in HIV/AIDS:

  • Microbicides: The International Partnership for Microbicides (IPM) is a nonprofit product development partnership whose mission is to identify a safe and effective microbicide for use by women in the developing world for the prevention of HIV transmission. SCI has provided IPM with a wide range of statistical consultation, including sample size, protocol development, and adaptive design.
  • HIV vaccine: Dr. Wittes served as a member of the Data Safety Monitoring Board (DSMB) for the Step Study that was sponsored jointly by NIAID and Merck.
  • Anti-retrovirals: SCI has consulted for various companies who have developed antiretroviral drugs.

Examples of publications:

  • Mocroft A, Neaton J, Bebchuk J, Staszewski S, Antunes F, Knysz B, Law M, Phillips AN, Lundgren J. The feasibility of clinical endpoint trials in HIV infection in the highly active antiretroviral treatment (HAART) era. Clinical Trials 2006; 206:119-132.