Statistics Collaborative, Inc. (SCI) has extensive experience working with clinical trials involving ophthalmological disorders. These underlying diseases have included diabetes as well as age-related disorders such as age-related macular degeneration (AMD). For clinical trials in ophthalmology, SCI has served as the statistical organization reporting to Data Monitoring Committees (DMCs) as well as the statistical member of the boards.
Dr. Wittes has served variously as the statistical member or as the Chair of the DMC for trials sponsored by the NEI. Illnesses have included AMD and cataracts (the Age-Related Eye Disease Study [AREDS] and the Age-Related Eye Disease Study 2 [AREDS2]), uveitis, and retinitis pigmentosa.
Ophthalmological disorders present unique statistical challenges because of their many outcomes and the paired nature of the data (with each subject having two eyes). SCI has designed unique graphical presentations to summarize changes over time in these multivariate data.